François the 1st hunting the enemy of Provence, but it is beaten and taken in Pavia (1525).
Taken along to Madrid, it covers freedom only while renonçant, by the treaty of Madrid, in Italy and Burgundy (1526).
But at once free, François 1st concludes from the alliances skilfully prepared by his Louise mother of Savoy, and starts again the war with the assistance of England, the Pope and the Sultan.
This second war is undecided: Rome is taken and plundered by the German mercenaries of the duke of Bourbon (1527); a French Army delivers the Pope and invades the kingdom of Naples, but it cannot there be maintained.
Charles-Quint, frightened by the invasion of the Turks in Hungary, accepts the Cambric treaty, by which it gives up Burgundy and François 1st Italy (1529).